Dan Alanine

dan alanine

Dan Alanine primarily worked with Simon Draper, where he pioneered the study of the human antibody response to vaccination with RH5. We were delighted that he joined us to solve structures of RH5 bound to antibodies targeting the two key neutralising epitopes on RH5. Dan also discovered a novel class of antibodies which potentiate the inhibitory effects of the most effective neutralising antibodies without themselves having any inhibitory activity. 

Dan has continued in the world of therapeutically important antibodies, most recently producing therapeutic monoclonals for veterinary medicine. 

Publications while working with the Higgins lab:

Alanine, D.G.W, Quinkert, D., Kumarasingha, R., Mehmood, S., Donnellan, F.R., Minkah, N.K., Dadonaite, B., Diouf, A., Galaway, F., Silk, S.E., Jamwal, A., Marshall, J.M., Miura, K., Foquet, L., Elias, S.C., Labbé, G.M., Douglas, A.D., Jin, J., Payne, R.O., Illingworth, J., Pattinson, D.J., Pulido-Gomez, D., Williams, B.G., de Jongh, W.A., Wright, G.J., Kappe, S.H.I., Robinson, C.V., Long, C.A., Crabb, B.S., Gilson, P.R., Higgins, M.K.* and Draper, S.J.*. (2019) Human antibodies that slow erythrocyte invasion potentiate malaria-neutralizing antibodies. Cell 178 216-228

Rawlinson, T.A., Barber, N.M., Mohring, F., Cho, J.S., Kosaisavee, V., Gérard, S.F., Alanine, D.G.W.,Labbé, G.M., Elias. S.C., Silk, S.E., Quinkert, D., Jin, J., Marshall, J.M., Payne, R.O., Minassian, A.M., Russell, B., Rénia, K., Nosten. F.H., Moon, R.W., Higgins, M.K.* and Draper, S.J.* (2019) Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralising vaccine-induced human antibody. Nature Microbiology 4 1497-1507