Gautier Courbon

gautier courbon

Gautier joined the lab as a postdoctoral research associate in June 2026 and will be investigating how human-infective trypanosomes evade innate immunity. Before joining the lab, Gautier completed his PhD at the Hospital for Sick Children in Toronto under the supervision of John Rubinstein. There, he used cryo-electron microscopy and biochemical methods to study the structure, function and inhibition of tuberculosis drug targets.

Courbon, G. M.*, Makarov, V., Cole, S. T., Schnapinger, D., Ehrt, S., Rubinstein, J. L.* (2026). Structural basis for EtfD-mediated coupling of β-oxidation and the respiratory chain in mycobacteria. The EMBO journal, 45(8), 2785-2807. (*Corresponding authors)

Di Trani, J. M., Yu, J.*, Courbon, G. M.*, Lobez Rodriguez, A. P.*, Cheung, C. Y.*, Liang, Y., ... Rubinstein, J. L. (2025). Cryo-EM of native membranes reveals an intimate connection between the Krebs cycle and aerobic respiration in mycobacteria. Proceedings of the National Academy of Sciences, 122(8), e2423761122. (*Equal Contribution)

Coupland, C. E., Karimi, R., Bueler, S. A., Liang, Y., Courbon, G. M., Di Trani, J. M., ... Rubinstein, J. L. (2024). High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles. Science, 385(6705), 168-174.

Harden, S. A., Courbon, G. M., Liang, Y., Kim, A. S., Rubinstein, J. L. (2024). A simple assay for inhibitors of mycobacterial oxidative phosphorylation. Journal of Biological Chemistry, 300(1), 105483.

Courbon, G. M., Palme, P. R., Mann, L., Richter, A., Imming, P., Rubinstein, J. L. (2023). Mechanism of mycobacterial ATP synthase inhibition by squaramides and second generation diarylquinolines. The EMBO Journal, 42(15), e113687.

Courbon, G. M., Rubinstein, J. L. (2022). CryoEM reveals the complexity and diversity of ATP synthases.Frontiers in Microbiology, 13, 864006.

Guo, H.*, Courbon, G. M.*, Bueler, S. A., Mai, J., Liu, J., Rubinstein, J. L. (2021). Structure of mycobacterial ATP synthase bound to the tuberculosis drug bedaquiline. Nature, 589(7840), 143-147. (*Equal Contribution)