Harriet Lane-Serff

harriet lane serff

Harriet Lane-Serff joined us as an undergraduate for her final year research project, before returning to the lab’ as a D. Phil. student, funded by the Wellcome Trust program in Cellular Structural Biology. She made major contributions to our understanding of the trypanosome surface, solving the structure of the haptoglobin-haemoglobin receptor in complex with haptoglobin-haemoglobin and investigating the evolutionary divergence of the receptor across different trypanosome species. Harriet also pioneered our studies of apolipoprotein LI, the active component of trypanolytic factor.

Harriet is now a research scientist at Adaptimmune.

Publications while in the Higgins lab:

Zoll, S., Lane-Serff, H., Mehmood, S., Robinson, C.V., Carrington, M. and Higgins, M.K. (2018) The structure of the serum resistance associated protein of Trypanosoma brucei rhodesiense and its implications for human infectivity. Nature Microbiology 3 295-301

Higgins, M.K., Lane-Serff, H., MacGregor, P. and Carrington, M. (2017) A receptor’s tale: an eon in the life of a trypanosome receptor. PLoS Pathogen 13 e1006055

Lane-Serff, H., MacGregor, P., Peacock, L., Macleod, O.J., Kay, C., Gibson, W., Higgins, M.K.* and Carrington, M.* (2016) Evolutionary diversification of the trypanosome haptoglobin-haemoglobin receptor from an ancestral haemoglobin receptor. eLife 5 e13044

Lane-Serff, H., McGregor, P., Lowe, E.D., Carrington, M. and Higgins, M.K. (2014) Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor. eLife 3 e05553