Ivan Campeotto

Ivan Campeotto spent four years with us as a postdoctoral research fellow. He led our program of structure-guided design for RH5-based vaccine components. An early success was the thermal stabilisation of RH5, generating a molecule which can be more easily produced and with increased stability. More to come as his later designs are still in pre-clinical testing!

In 2018 Ivan moved to the University of Leicester to start his own research program and in April 2020 he started a lectureship at Nottingham Trent University. In 2022 he moved to take up an Associate Professorship at the University of Nottingham (https://www.nottingham.ac.uk/biosciences/people/ivan.campeotto).

Publications while in the Higgins lab:

Campeotto, I., Goldenzweig, A., Davey, J., Barfod, L., Marshall, J.M., Silk, S.E., Wright, K.E., Draper, S.J., Higgins, M.K.* and Fleishman, S.J.* (2017) One-step design of a stable variant of the malaria invasion protein RH5 for use as a vaccine immunogen. Proc Natl Acad Sci U S A. 114 998-1002

Warszawski, S., Dekel, E., Campeotto, I., Marshall, J.M., Wright, K.E., Lyth, O., Knop, O., Regev-Rudzki, N., Higgins, M.K., Draper, S.J., Baum, J. and Fleishman, S.J. (2019) Design of a basigin-mimicking inhibitor targeting the malaria invasion protein RH5. Proteins 88 187-195

Campeotto, I., Galaway, F., Mehmood, S., Barfod, L.K., Quinkert, D., Kotraiah, V., Phares, T.W., Wright, K.E., Snijders, A.P., Draper, S.J., Higgins, M.K., Wright, G.J. (2020) The Structure of the Cysteine-Rich Domain of Plasmodium falciparum P113 Identifies the Location of the RH5 Binding Site. mBio 11 e01566-20.

Harrison, T.E., Alam, N., Farrell, B., Quinkert, D., Lias, A.M., King, L.D., Draper, S.J., Campeotto, I. * and Higgins, M.K.* (2024) Rational structure-guided design of a blood stage malaria vaccine immunogen presenting a single epitope from PfRH5. EMBO Molecular Medicine 16 2539-59 (* equal corresponding)