Natalie Barber

Natalie joined us in 2015 as a D. Phil. student funded by the Wellcome Trust program in Cellular Structural Biology and successfully defended her thesis in December 2019. She has used structural studies to investigate the inhibition of Plasmodium vivax reticulocyte invasion by a broadly neutralising antibody, and to assess a synthetic EPCR-binding protein.

Before joining us, Natalie achieved a first-class degree from the University of Oxford undergraduate course in Biochemistry, and worked with Professor Susan Lea to assess inhibitors of the complement system. Natalie has now started a graduate medicine course.

Publications

Jore MM, Johnson S, Sheppard D, Barber NM, Li YI, Nunn MA, Elmlund H, Lea SM. (2016) Structural basis for therapeutic inhibition of complement C5. Nat Struct Mol Biol. 23 378-86

Rawlinson, T.A.*, Barber, N.M.*, Mohring, F., Cho, J.S., Kosaisavee, V., Gérard, S.F., Alanine, D.G.W., Labbé, G.M., Elias. S.C., Silk, S.E., Quinkert, D., Jin, J., Marshall, J.M., Payne, R.O., Minassian, A.M., Russell, B., Rénia, K., Nosten. F.H., Moon, R.W., Higgins, M.K. and Draper, S.J. (2019) Structural basis for inhibition of Plasmodium vivax invasion by a broadly neutralising vaccine-induced human antibody.Nature Microbiology 4 1497-1507 (*joint first author)

Barber, N.M., Lau, C.Y.K., Turner, L., Watson, G., Thrane, S., Lusingu, J.P.A., Lavstsen, T and Higgins, M.K. (2019) Structure-guided design of a synthetic mimic of an EPCR-binding PfEMP1 protein. BioRXIVdoi 10.1101/749432